Pain management is a main determinant of functional recovery after total knee arthroplasty ( TKA ). Local infiltration analgesia ( or cocktail therapy ) known as a periarticular infiltration technique in operations with a combined administration of local anesthetics, epinephrine and other adjuvants, has gained increasing popularity in total knee arthroplasty. In this review, the latest progress of within-protocol comparisons and between-protocol comparisons are discussed.