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目的 :探讨喉癌患者手术前后的凝血状态。方法 :测定 46例喉癌患者行全喉切除术前 1天及术后第1、10天的凝血系统 8项参数 ,观察其测值的变化 ;并以 82例健康人为对照组 ,进行比较。结果 :患者术前即存在抗凝活性明显降低 ,并伴有纤溶活性增强 ,手术创伤使上述异常进一步加重。随着癌肿的切除和手术创伤的恢复 ,患者抗凝及纤溶系统逐渐恢复至正常水平。结论 :喉癌患者存在一定程度的凝血障碍 ,而手术能进一步加重其障碍程度 ,故临床上应高度重视对患者的抗凝及纤溶系统的监测 ,以防血栓及出血性疾病的发生。
Objective: To investigate the coagulation status of patients with laryngeal cancer before and after operation. Methods: Eight parameters of coagulation system were measured in 46 patients with laryngeal carcinoma one day before total laryngectomy and at the first and tenth day after operation. The changes of the measured values were observed. The healthy controls were taken as control group. Results: Preoperative anticoagulant activity was significantly reduced, accompanied by increased fibrinolytic activity, surgical trauma further aggravate the above abnormalities. With the removal of cancer and surgical trauma recovery, patients with anticoagulant and fibrinolytic system gradually returned to normal levels. Conclusion: There is a certain degree of coagulopathy in patients with laryngeal cancer, and surgery can further aggravate the degree of the disorder, so the clinical should attach great importance to the patient’s anticoagulant and fibrinolytic system monitoring to prevent thrombosis and hemorrhagic disease.