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目的探讨鼻腔及剐鼻窦内翻性乳头状瘤(NIP)中人乳头状瘤病毒(HPV)感染阳性率及感染细胞定位与肿瘤预后的关系。方法根据随访情况将67例 NIP 分为无复发组、复发组、癌变组,用原位杂交方法检测其 HPV 通用型及16/18型的感染率,并分析阳性细胞在上皮巢内的定位情况,以10例鼻黏膜炎性息肉病例为对照,并对结果进行统计分析。结果 NIP 中 HPV 总感染率高于炎性息肉组,其中复发组及癌变组 HPV 感染率又高于无复发组,癌变组以高危型(16/18)HPV 感染为主;两者阳性细胞定位有所不同,无复发组阳性细胞定位于黏膜表面或上皮细胞巢近腔面,复发组和癌变组部分阳性细胞靠近上皮细胞基底层。结论 HPV 感染同 NIP 的复发和癌变有关,原因可能是复发和癌变病例 HPV 感染范围更为广泛,癌变病例尚有高危型 HPV 感染。
Objective To investigate the positive rate of human papillomavirus (HPV) infection and the relationship between the location of infected cells and the prognosis of the patients with inverted papilloma (NIP) in nasal and popliteal sinus. Methods According to the follow-up, 67 cases of NIP were divided into non-recurrence group, recurrence group and carcinogenesis group. The HPV infection rate and 16/18 infection rate were detected by in situ hybridization. The localization of positive cells in epithelial nests , With 10 cases of nasal polyposis inflammatory polyp as control, and the results were statistically analyzed. Results The total HPV infection rate in NIP was higher than that in inflammatory polyp group. The HPV infection rate in recurrence group and cancerous group was higher than that in non-recurrence group. The high-risk (16/18) HPV infection was the most common in cancerous group. In contrast, positive cells in the non-relapse group were located on the mucosal surface or in the neovascular surface of epithelial cells, and some positive cells in the recurrence group and cancerous group were close to the basal layer of epithelial cells. Conclusions HPV infection is associated with recurrence and canceration of NIP, which may be due to the more extensive HPV infection in recurrent and cancerous cases and high-risk HPV infection in cancerous cases.