氯胺酮(Ketamine,KT)是常用的具有较强镇痛效应的静脉全麻药,但由于其不良反应较多,特别是心血管兴奋效应明显,临床已很少单独应用KT,而多采用联合用药。可乐定(Clonidine,CLO)是目前研究较多的α_2受体激动剂,可产生镇静、抗焦虑、镇痛、稳定围术期血流动力学、减少全麻药的用量等作用。有文献报道表明CLO可增强KT的催眠、镇痛等作用,并减轻其术后的精神运动性反应,已在临床应用。本实验旨在明确CLO对KT的心血管作用的确切影响,并初步探讨其可能的受体机制。 Ketamine (KT) is a commonly used intravenous anesthetics with strong analgesic effect. However, KT is rarely used clinically because of its adverse reactions, especially cardiovascular excitability. Clonidine (CLO) is currently the more studied α 2 receptor agonist, can produce sedation, anxiolytic, analgesic, stable perioperative hemodynamics, reduce the amount of anesthetic drugs and so on. It has been reported in the literature that CLO can enhance hypnosis, analgesia and other effects of KT, and reduce its postoperative psychomotor response, has been in clinical application. The purpose of this experiment was to determine the exact effect of CLO on the cardiovascular effects of KT and to explore its possible receptor mechanisms.