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目的观察慢性肾小球肾炎使用肾炎康复片联合贝那普利治疗的疗效。方法 100例慢性肾小球肾炎患者,按照治疗方案的不同分为联合组与贝那普利组,各50例。贝那普利组采用单纯贝那普利治疗,联合组使用肾炎康复片联合贝那普利治疗。比较两组患者的临床疗效、治疗后血压、24 h尿蛋白含量、肌酐水平及治疗期间不良反应发生情况。结果联合组患者总有效率90.00%高于贝那普利组70.00%,差异具有统计学意义(P<0.05)。治疗后,联合组血压稍低于贝那普利组,但差异均无统计学意义(t=0.6796、1.1744,P>0.05);联合组24 h尿蛋白含量及肌酐水平均低于贝那普利组,差异均具有统计学意义(t=2.8620、2.0576,P<0.05)。两组不良反应发生率均为6.00%,比较差异无统计学意义(P>0.05)。结论肾炎康复片联合贝那普利治疗慢性肾小球肾炎效果显著,能有效降低患者24 h尿蛋白含量,提高治疗效果,有在临床上普及、推广、使用价值。
Objective To observe the therapeutic effect of nephritis rehabilitation combined with benazepril on chronic glomerulonephritis. Methods One hundred patients with chronic glomerulonephritis were divided into the combined group and the benazepril group according to the treatment plan, 50 cases each. The benazepril group was treated with benazepril alone, and the combination group was treated with nephritis kangaroo and benazepril. The clinical efficacy, blood pressure after treatment, urinary protein content in 24 h, creatinine level and adverse reactions during treatment were compared between the two groups. Results The total effective rate in combination group was 90.00% higher than that in benazepril group 70.00%, the difference was statistically significant (P <0.05). After treatment, the blood pressure in the combined group was slightly lower than that in the benazepril group, but the difference was not statistically significant (t = 0.6796,1.1744, P> 0.05); the 24 h urinary protein content and creatinine in the combination group were lower than those in the benazepril group Lee group, the differences were statistically significant (t = 2.8620,2.0576, P <0.05). Adverse reactions in both groups were 6.00%, with no significant difference (P> 0.05). Conclusion Shenyinkang tablets combined with benazepril treatment of chronic glomerulonephritis significant effect, can effectively reduce 24 h urinary protein content and improve the therapeutic effect, in clinical popularization, promotion and use value.