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目的调查和分析尿路感染假丝酵母菌的分布及耐药情况,为临床合理选用抗菌药物提供依据。方法尿液采用经典型浸片Uricult培养,使用ATB-Fungus板条进行药敏试验,利用WHONET 5.6对浙江萧山医院2008年1月至2012年12月间尿培养分离菌株及药敏结果进行回顾性分析。结果共分离出假丝酵母菌273株,其中白假丝酵母菌占37.4%,光滑假丝酵母菌28.9%、热带假丝酵母菌27.8%;临床分离数量以ICU(58)最多,其次为泌尿外科(50)和内科(49)。药敏结果显示:两性霉素B、5-氟胞嘧啶对白假丝酵母菌、热带假丝酵母菌和光滑假丝酵母菌仍保持较强的抗菌活性,敏感率≥98.6%,伏立康唑敏感率≥86.3%。结论尿路感染分离得到的假丝酵母菌以白假丝酵母菌为主,其次为光滑假丝酵母菌和热带假丝酵母菌;两性霉素B、5-氟胞嘧啶对假丝酵母菌保持较强的抗菌活性,是治疗假丝酵母菌感染的首选药物。临床应重视假丝酵母菌的培养和其药敏试验,根据药敏结果科学合理使用抗真菌药物。
Objective To investigate and analyze the distribution and drug resistance of Candida albicans in urinary tract infection and provide basis for the rational use of antibacterials in clinic. Methods Urinary samples were cultured with Uricult, a classic immersion strip. Susceptibility tests were performed using ATB-Fungus slats. WHYET 5.6 was used to retrospectively isolate and isolate susceptible strains of urinary cultures from January 2008 to December 2012 in Zhejiang Xiaoshan Hospital analysis. Results 273 strains of candida were isolated, of which Candida albicans accounted for 37.4%, Candida glabrata 28.9% and Candida tropicalis 27.8%. The number of clinical isolates was ICU (58), followed by urinary Surgery (50) and Internal Medicine (49). The results of drug sensitivity showed that amphotericin B and 5-fluorocytosine still maintained strong antibacterial activity against Candida albicans, Candida tropicalis and Candida glabrata with the sensitivity of ≥98.6% and the sensitivity of voriconazole≥ 86.3%. Conclusion Candida albicans isolated from urinary tract infection is mainly Candida albicans, followed by Candida glabrata and Candida tropicalis. Amphotericin B and 5-fluorocytosine are retained for Candida albicans Strong antibacterial activity, is the treatment of Candida infection of choice for drugs. Clinical should pay attention to the culture of Candida and its drug sensitivity test, according to the scientific and rational use of anti-fungal drug results.