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目的观察达英-35联合二甲双胍治疗多囊卵巢综合征的临床疗效。方法 70例符合纳入标准的多囊卵巢综合征患者,依据就诊先后顺序,用随机数字表法随机(1∶1)分为两组各35例。对照组在月经周期或撤退性出血第5d,给予达英-35,每晚睡前1片,口服,连用21d为1个周期,6个周期为1个疗程;治疗组在对照组基础上,加用二甲双胍片,500mg/次,3次/d,口服,疗程同对照组,中间不停药。结果 2组FSH与治疗前比较无显著性差异(P>0.05);LH、T较治疗前均有显著下降(P<0.05),但两组比较无显著性差异(P>0.05);治疗组BMI、WHR、GIR、排卵率与治疗前、对照组比较,均有显著性差异(P<0.05)。结论达英-35联合二甲双胍治疗多囊卵巢综合征在改善症状,降低LH、T、BMI、WHR、GIR,促进卵泡发育均有较好的作用,优于单用达英-35。
Objective To observe the curative effect of Da Ying-35 combined with metformin on polycystic ovary syndrome. Methods Seventy patients with polycystic ovary syndrome who met the inclusion criteria were randomly divided into two groups of 35 cases (1: 1) randomly according to the order of their visits. The control group in the menstrual cycle or withdrawal bleeding on the 5th day, given up Ying -35, 1 night before bed, orally, once every 21d for a cycle, 6 cycles for a course of treatment; treatment group on the basis of the control group, Add metformin tablets, 500mg / time, 3 times / d, oral, treatment with the control group, the middle of non-stop medicine. Results There was no significant difference in FSH between the two groups before treatment (P> 0.05). LH and T were significantly lower than those before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05) BMI, WHR, GIR, ovulation rate compared with before treatment and control group, there was a significant difference (P <0.05). Conclusions Da-Ying-35 combined with metformin in the treatment of polycystic ovary syndrome in improving symptoms, reduce LH, T, BMI, WHR, GIR, promote follicular development have a better effect, better than single-Ying Ying -35.