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目的探讨坐骨海绵体肌损伤对勃起功能障碍的影响及坐骨海绵体肌在勃起机制中的作用。方法选用生殖期雄性大白鼠35只,随机分为手术组(25只)、假手术组(5只)和非手术组(5 只),手术组切断双侧坐骨海绵体肌,假手术组仅显露双侧坐骨海绵体肌后关闭切口。手术1周后选用育龄期雌性大白鼠35只,随机与手术组、假手术组和非手术组一一配对饲养,观察2个月,了解三组配对雌鼠受孕情况。结果手术组雄鼠死亡2只,雌鼠1只受孕,受孕率4.35%。假手术组雄鼠死亡1只,雌鼠4只受孕,受孕率100%。非手术组5只雌鼠均受孕,受孕率100%。手术组与假手术组、非手术组雌鼠受孕情况比较差异有非常显著性(P<0.001),而假手术组与非手术组差异无统计学意义。结论切断雄鼠双侧坐骨海绵体肌必然导致勃起功能障碍,引起不育。坐骨海绵体肌在阴茎勃起机制中不可缺少。
Objective To investigate the effect of ischial sponge muscle injury on erectile dysfunction and the effect of ischial sponge muscle on erectile dysfunction. Methods 35 male rats of reproductive age were randomly divided into operation group (25 rats), sham operation group (5 rats) and non-operation group (5 rats). The operation group was used to cut the bilateral ischial muscle and the sham operation group Revealed bilateral ischial sponge muscle closed incision. One week after surgery, 35 females of childbearing age were selected and randomly fed to the operation group, the sham operation group and the non-operation group for one month, and observed for 2 months to understand the pregnancy status of the matched female rats. Results There were 2 males died in the surgery group and 1 females in one pregnancy, the pregnancy rate was 4.35%. One male adult died in the sham-operation group and four female rats were pregnant, with a conception rate of 100%. Non-surgical group of 5 females were pregnant, pregnancy rate of 100%. There were significant differences in the pregnancy status between the operation group and the sham operation group and the non-operation group (P <0.001), while the difference between the sham operation group and the non-operation group was not statistically significant. Conclusion Severing both sides of the sciatic cavernous muscles of the male will inevitably lead to erectile dysfunction and cause infertility. Ischiatic sponge muscle is indispensable in the mechanism of penile erection.