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目的:探讨动脉瘤性SAH后症状性脑血管痉挛与病人外周血清高凝状态的相关性,同时观察应用丹参注射液对血液高凝状态的影响。方法:60例动脉瘤性蛛网膜下腔出血(SAH)病人,出现症状性脑血管痉挛38例,症状性脑血管痉挛组随机分为丹参治疗组和非丹参治疗组。所有病人分别在住院时、3天、7天、14天、21天,进行周围血中FDP和D-dimer含量的测定并进行动态观察。结果:症状性脑血管痉挛组病人FDP和D-dimer的含量在住院后各时间段明显高于非症状性脑血管痉挛组(P<0.01),住院后第14天、21天丹参治疗组FDP和D-dimer的含量明显低于非丹参治疗组(P<0.05)。症状性脑血管痉挛组中,丹参治疗组病人的预后明显优于非丹参治疗组。结论:动脉瘤性SAH引起症状性脑血管痉挛与血粘稠度增高有明显关系。丹参注射液可明显降低血粘稠度,促进脑血液循环对改善症状性脑血管痉挛的脑缺血症状有明显的治疗作用。
Objective: To investigate the relationship between symptomatic cerebral vasospasm and hypercoagulability in peripheral blood of patients after aneurysmal SAH, and to observe the effect of Danshen injection on hypercoagulability of blood. Methods: Sixty patients with aneurysmal subarachnoid hemorrhage (SAH) developed symptomatic cerebral vasospasm and 38 patients with symptomatic cerebral vasospasm were randomly divided into three groups: Salvia miltiorrhiza group and non-salvia miltiorrhiza group. All patients were in hospital, 3 days, 7 days, 14 days, 21 days, the determination of peripheral blood FDP and D-dimer content and dynamic observation. Results: The contents of FDP and D-dimer in patients with symptomatic cerebral vasospasm were significantly higher than those in patients with non-symptomatic cerebral vasospasm at each time after hospitalization (P <0.01). On the 14th and 21st days after hospitalization, And D-dimer were significantly lower than the non-Salvia treatment group (P <0.05). Symptomatic cerebral vasospasm group, Salvia treatment group patients prognosis was significantly better than the non-Salvia treatment group. Conclusions: Aneurysmal SAH causes a significant relationship between symptomatic cerebral vasospasm and increased blood viscosity. Danshen injection can significantly reduce blood viscosity and promote cerebral blood circulation to improve symptomatic cerebral vasospasm of cerebral ischemic symptoms have a significant therapeutic effect.