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目的 研究肝细胞癌（HCC)凋亡在浸润转移过程中的重要性。方法 采用DNA 原位末端标记法（ISEL）、光镜、电镜，并结合计算机图象分析技术定量检测55例HCC的凋亡发生情况。结果 低分化HCC凋亡指数低于高分化HCC （Ｐ<0.05），浸润性和转移性HCC的凋亡指数分别低于非浸润性和无转移HCC（Ｐ<0.05和Ｐ<0.01）。结论 HCC凋亡指数与肿瘤的某些生物学特性有密切的联系，细胞凋亡的异常改变可能在HCC的浸润转移过程中起重要作用。
Objective To study the importance of apoptosis of hepatocellular carcinoma (HCC) during invasion and metastasis. Methods The apoptosis of 55 HCC patients was quantitatively detected by ISEL, light microscope and electron microscope combined with computer image analysis. Results The apoptotic index of poorly differentiated HCC was lower than that of well-differentiated HCC (P <0.05). The apoptosis index of invasive and metastatic HCC was lower than that of non-invasive and metastatic HCC respectively (P <0.05 and P <0.01). Conclusion The apoptosis index of HCC is closely related to some biological characteristics of the tumor. Abnormal changes of apoptosis may play an important role in the invasion and metastasis of HCC.