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作者研究了直肠温度升高关于酒精毒性的影响以及酒精对平均致死温度(LT 50的影响。直肠温度维持在予定的水平,4小时将酒1精(23%W/V)作 i.p.注射。在对照组小鼠用戊巴比妥麻醉,其4小时的 LT 50是41.8±0.1℃(平均数±标准误)。给小鼠一个非致死剂量的酒精(6g/kg)时 LT 50减少至39.0±0.2℃(P<0.001)。对照组体温下降4小时的 LD 为8.5±0.8g/kg,如果小鼠直肠温度维持在38.5～40℃
The authors investigated the effects of elevated rectal temperature on alcohol toxicity and the effect of alcohol on the mean lethal temperature (LT50.) The rectal temperature was maintained at a pre-determined level and alcohol (1%, w / v) was ip injected at 4 hours. Control mice were anesthetized with pentobarbital and had a LT50 for 4 hours of 41.8 ± 0.1 ° C (mean ± standard error). The LT 50 was reduced to 39.0 for mice given a non-lethal dose of alcohol (6 g / kg) ± 0.2 ℃ (P <0.001) .In the control group, the LD decreased by 8.5 ± 0.8g / kg when the body temperature decreased by 4 hours. If the rectal temperature of the mouse was maintained at 38.5 ~ 40 ℃