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目的观察低分子肝素(LMWH)在治疗不稳定性心绞痛(UA)中的作用。方法对200例UA患者随机分成对照组和LMWH治疗组,对照组采用硝酸酯制剂、钙拮抗剂、β受体阻滞剂、肠溶阿斯匹林等药常规治疗,LMWH治疗组在上述用药基础上加用LMWH(速避凝),每次0.4ml,每日两次,腹壁皮下注射,治疗7～10d。对照组和治疗组在两周后观察日均心绞痛发作次数、每次发作平均持续时间、心电图ST段及T波变化、副作用(有否出血)。结果LMWH组治疗后两周日均心绞痛发作次数及平均每次持续时间较对照组均显著减少,心电图ST段及T波改善较对照组显著增加,P<0.05。结论LMWH抑制了血液有形成分的聚集,从而有效地预防血栓形成,在UA的治疗中具有广阔前景。
Objective To observe the effect of low molecular weight heparin (LMWH) in the treatment of unstable angina pectoris (UA). Methods 200 patients with UA were randomly divided into control group and LMWH treatment group. The control group was treated with nitrates, calcium antagonists, β-blockers and enteric-coated aspirin. LMWH treatment group Based on the use of LMWH (speed Avoidance), each 0.4ml, twice daily, abdominal subcutaneous injection, the treatment of 7 ~ 10d. The control group and the treatment group were observed two weeks after the average number of angina attacks, the average duration of each episode, ECG ST segment and T wave changes, side effects (whether or not bleeding). Results The average number of episodes of angina pectoris and the average duration of each episode in the two weeks after LMWH treatment were significantly lower than those in the control group. The improvement of ST segment and T wave in ECG in the LMWH group was significantly higher than that in the control group (P <0.05). Conclusion LMWH inhibits the accumulation of blood components, which can effectively prevent thrombosis and has broad prospects in the treatment of UA.