论文部分内容阅读
目的:探讨血清胱抑素C(CysC)在造影剂肾损伤早期诊断中的价值。方法:选取300例行冠状动脉造影的患者,术前及术后24、48、72h分别测定血清CysC、血尿素氮、血肌酐和尿微量白蛋白。采用MDRD简化公式计算肾小球滤过率(eGFR)。结果:与术前比较,术后24和48h血清CysC浓度明显升高(P<0.05),术后72h无明显差异;术后24、48及72h的eGFR、血尿素氮、血肌酐、尿微量白蛋白水平变化差异无统计学意义。相关性分析提示,血清CysC与eGFR呈明显负相关性(r=-0.657,P<0.01)。结论:血清CysC是反映造影剂早期肾损伤的有效指标之一。
Objective: To investigate the value of serum cystatin C (CysC) in the early diagnosis of contrast-induced renal injury. Methods: Serum CysC, blood urea nitrogen, serum creatinine and urine microalbumin were measured in 300 patients undergoing coronary angiography at 24, 48 and 72 hours after operation. Glomerular filtration rate (eGFR) was calculated using the MDRD reduction formula. Results: The levels of serum CysC at 24 and 48 hours after operation were significantly higher than those before operation (P <0.05), but there was no significant difference at 72 hours after operation. The levels of eGFR, blood urea nitrogen, serum creatinine, There was no significant difference in albumin level. Correlation analysis showed that serum CysC was negatively correlated with eGFR (r = -0.657, P <0.01). Conclusion: Serum CysC is one of the effective indicators of contrast-induced early renal injury.