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目的探讨碳酸镧在慢性肾衰竭持续非卧床腹膜透析(CAPD)患者应用骨化三醇治疗继发性甲状旁腺功能亢进(SHPT)时对血钙和血磷的影响。方法将2013年3~6月青岛市市立医院东院腹膜透析中心的CAPD导致SHPT的患者随机分为两组。碳酸镧组予以口服碳酸镧和骨化三醇冲击治疗,碳酸钙组给予碳酸钙和骨化三醇治疗,观察患者血清钙、磷、iPTH的变化。统计分析采用SPSS 17.0软件。结果共纳入40例患者,两组各20例。治疗12周后,碳酸镧组患者血磷(t=5.095,P=0.000)和iPTH(t=1.225,P=0.000)水平均明显下降,且碳酸镧组血钙(t=1.127,P=0.001)、血磷(t=2.035,P=0.000)水平明显低于碳酸钙组。结论碳酸镧能有效治疗CAPD患者应用骨化三醇冲击治疗SHPT时的高钙血症和高磷血症。
Objective To investigate the effects of lanthanum carbonate on serum calcium and phosphorus in patients with chronic obstructive pulmonary disease (CPD) with chronic renal failure and calcitriol treatment of secondary hyperparathyroidism (SHPT). Methods From March to June 2013, patients with SHD caused by CAPD in the peritoneal dialysis center of the Eastern Hospital of Qingdao Municipal Hospital were randomly divided into two groups. Lanthanum carbonate group was treated with oral administration of lanthanum carbonate and calcitriol. Calcium carbonate group and calcitriol treatment group were used to observe the changes of serum calcium, phosphorus and iPTH. Statistical analysis using SPSS 17.0 software. Results A total of 40 patients were enrolled, with 20 patients in each group. The levels of serum phosphorus (t = 5.095, P = 0.000) and iPTH (t = 1.225, P = 0.000) in the lanthanum carbonate group decreased significantly after 12 weeks of treatment, ), Serum phosphorus (t = 2.035, P = 0.000) was significantly lower than the calcium carbonate group. Conclusion Lanthanum carbonate can effectively treat hypercapnia and hyperphosphatemia in CAPD patients treated with calcitriol shock.