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苯乙酸是制造香料、药物及植物激素的重要原料。目前,工业上系由苄氯与氰化钠作用,所得的苯乙腈经水解而制得。氰化钠剧毒,给操作者和环境带来危害和污染。 1976年,L.Cassar以Pd(Ph_3P)_2Cl_2为催化剂,使用5×10~5帕的CO,通过相转移催化羰化合成了苯乙酸,其产率为83％。1982年,Howard Alper发表了用Pd(Ph_3P)_4为催化剂,苄基溴作原料,在常温常压下合成苯乙酸的报告,所得产率为84％。 本文以Pd(Ph_3P)_2Cl_2为羰化催化剂,氯化三乙基苄基铵为相转移催化剂,在常压下由CO与苄基氯作用合成了苯乙酸,其产率高于80％,且催化剂可以循环使用。
Phenylacetic acid is an important raw material for the manufacture of perfumes, pharmaceuticals and plant hormones. At present, the industrial department by benzyl chloride and sodium cyanide role, the resulting benzene acetonitrile obtained by hydrolysis. Sodium cyanide is highly toxic, bringing harm and pollution to operators and the environment. In 1976, with the Pd (Ph_3P) _2Cl_2 as catalyst, L. Cassar synthesized phenylacetic acid by phase transfer catalytic carbonylation using 5 × 10 ~ 5 Pa and its yield was 83%. In 1982, Howard Alper published a report on the synthesis of phenylacetic acid using Pd (Ph_3P) _4 as catalyst and benzyl bromide as starting material at normal temperature and pressure. The yield was 84%. In this paper, Pd (Ph_3P) _2Cl_2 was used as carbonylation catalyst and triethylbenzylammonium chloride was used as phase transfer catalyst. Phenylacetic acid was synthesized from CO and benzyl chloride under normal pressure. The yield was above 80% The catalyst can be recycled.