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目的研究氯沙坦对高血压合并阵发性心房颤动的影响及可能的机制。方法将63例患者分为治疗组与对照组,两组均口服胺碘酮,治疗组加用氯沙坦100mg/d,疗程12个月,对照组用长效硝苯吡啶25mg,每天2次,监测6个月、12个月心房颤动的复发率与6个月、12个月左心房内径值。结果治疗组治疗后6个月心房颤动复发率较对照组低,12个月后左心房内径小于对照组,以上两组比较差异有统计学意义(P<0.05)。结论胺碘酮联合氯沙坦治疗阵发性心房颤动能够减少心房颤动的发生,并能抑制左心房扩大。其机制可能与改善心房的组织重构有关。
Objective To study the effect of losartan on hypertension with paroxysmal atrial fibrillation and its possible mechanism. Methods Sixty-three patients were divided into treatment group and control group. Both groups were given amiodarone orally. The treatment group was given losartan 100 mg / d for 12 months. The control group was given long-acting nifedipine 25 mg twice daily , Monitoring 6 months, 12 months recurrence rate of atrial fibrillation and 6 months, 12 months left atrial diameter values. Results The recurrence rate of atrial fibrillation was lower in the treatment group than in the control group 6 months after the treatment. The diameter of the left atrium was smaller than that in the control group after 12 months. There was significant difference between the two groups (P <0.05). Conclusion Amiodarone combined with losartan in the treatment of paroxysmal atrial fibrillation can reduce the occurrence of atrial fibrillation and inhibit left atrial enlargement. The mechanism may be related to the improvement of atrial tissue remodeling.