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目的分析经皮冠状动脉介入治疗术对冠状动脉微循环的影响。方法回顾性分析2013年1月~2014年12月本院收治的130例冠心病患者临床资料,患者均予以经皮冠状动脉介入术治疗,对比患者手术前后冠状动脉微循环阻力指数(IMR)与高敏C-反应蛋白水平(hs-CRP)。结果患者经皮冠状动脉球囊扩张(PTCA)及支架植入后IMR水平均高于术前,差异均有统计学意义(p<0.05),但PTCA后与支架植入后无明显差异(p>0.05);患者的股动脉、冠状窦hs-CRP水平在PTCA后与支架植入后均明显升高,前后对比差异有统计学意义(p<0.05)。结论经皮冠状动脉介入治疗术可致冠心病患者术后IMR与hs-CRP水平升高,考虑与手术器械压迫冠状动脉血管壁致动脉粥样硬化斑块破裂及血管内皮损伤相关,从而导致冠状动脉的微循环障碍与炎症反应。
Objective To analyze the effect of percutaneous coronary intervention on coronary microcirculation. Methods The clinical data of 130 patients with coronary heart disease admitted to our hospital from January 2013 to December 2014 were retrospectively analyzed. All patients underwent percutaneous coronary intervention (PCI). The changes of coronary microcirculation resistance index (IMR) and High-sensitivity C-reactive protein (hs-CRP). Results The patients with percutaneous coronary artery balloon dilatation (PTCA) and IMR levels after stent implantation were significantly higher than those before operation (p <0.05), but there was no significant difference after PTCA and stent implantation (p > 0.05). The level of hs-CRP in the femoral artery and coronary sinus of patients was significantly increased after PTCA and stent implantation, with significant difference between before and after treatment (p <0.05). Conclusion Percutaneous coronary intervention can cause postoperative IMR and hs-CRP levels in patients with coronary heart disease, which is related to the rupture of atherosclerotic plaque and the injury of the vascular endothelial cells caused by the compression of the coronary artery wall by surgical instruments, resulting in coronal Arterial microcirculation disorders and inflammatory responses.