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恶性肿瘤的发生和发展是一个多基因参与,通过多步骤完成的复杂过程。其中转移过程包括细胞因子诱导的癌细胞特异性定向归巢,增强癌细胞粘附到器官微血管内皮的能力以及肿瘤血管和淋巴管生成等诸多因素,并表现出高度的组织特异性和器官靶向性,而靶器官必须拥有适当的趋化因子才能使受体阳性的肿瘤细胞更容易发生迁移并进行生长繁殖。最重要的趋化因子是CXCL12,它与其受体CXCR7或CXCR4组成的生物轴在恶性肿瘤播散和器官特异性转移中发挥重要作用。本文就近几年CXCL12/CXCR7/CXCR4生物轴及其与口腔肿瘤发生发展的研究进展进行综述。
The occurrence and development of malignant tumor is a multi-gene involved in the complex process through multiple steps. Among them, the metastasis process includes cytokine-induced cancer cell-specific homing, enhanced ability of cancer cells to adhere to the organ microvascular endothelium and many factors such as tumor blood vessels and lymphangiogenesis, and shows a high degree of tissue specificity and organ targeting However, the target organ must have the appropriate chemotactic factor to make the recipient-positive tumor cells more easily migrate and grow. The most important chemokine is CXCL12, whose biological axis with its receptor CXCR7 or CXCR4 plays an important role in the spread of malignant tumors and organ-specific metastases. This review summarizes the recent advances in the biological axis of CXCL12 / CXCR7 / CXCR4 and the development of oral tumor.