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目的分别对肝细胞癌炎症微环境和其上皮-间质转化过程进行介绍,并对二者之间的关系做一综述。方法通过对国内外相关文献的查阅和筛选,对上皮-间质转化与肝细胞癌炎症微环境二者之间的关系进行归纳和总结。结果肝细胞癌炎症微环境中的许多炎症因子以及病毒基因编码蛋白都在其肿瘤的上皮-间质转化过程中扮演了重要角色,对肿瘤的侵袭转移推波助澜。结论肝细胞癌的炎症微环境是其上皮-间质转化过程中不可或缺的角色,其炎症微环境的抑制和治疗可能在控制肿瘤侵袭转移方面起到更加积极的作用。
Objective To introduce the inflammatory microenvironment and epithelial-mesenchymal transition of hepatocellular carcinoma, and to review the relationship between the two. Methods The relationship between epithelial-mesenchymal transition and inflammatory microenvironment of hepatocellular carcinoma was summarized and summarized through reviewing and screening of related literatures at home and abroad. Results Many inflammatory factors in hepatocellular carcinoma inflammation microenvironment and viral gene-encoded proteins play an important role in the epithelial-mesenchymal transition of their tumors, contributing to tumor invasion and metastasis. Conclusion The inflammatory microenvironment of HCC is an indispensable part of epithelial-mesenchymal transition. The inhibition and treatment of inflammatory microenvironment may play a more active role in the control of tumor invasion and metastasis.