反复性流产指排除患有解剖、内分泌、染色体等异常和生殖道感染疾病因素而自然流产连续3次以上的患者。近年来研究认为40%~65%与免疫因素有关~([1]),有必要对其进行深入研究,以作针对性治疗。从生殖免疫学观点上讲,正常情况下由于母-胎界面的免疫耐受使胚胎不被母体所排斥,而如果这一“母-胎界面的免疫耐受”格局被打破,就会导致反复流产的发生~([2])。最新研究表明反复流产与自然杀 Repeated abortion refers to the exclusion of patients with anatomical, endocrine, chromosomal abnormalities and reproductive tract infections and other factors of natural abortion for more than 3 consecutive patients. In recent years, studies suggest that 40% ~ 65% are related to immune factors ~ ([1]), it is necessary to conduct in-depth study for targeted treatment. From a reproductive immunology point of view, embryos are normally not rejected by the mother due to immune tolerance at the maternal-fetal interface, and if this pattern of “immune tolerance” at the maternal-fetal interface is broken, Lead to recurrent miscarriage occurred ~ ([2]). The latest research shows repeated abortion and natural kill