目的:探讨妊娠合并乙型肝炎患者血脂及雌激素水平检测的临床意义。方法:选择十堰市妇幼保键院收治的160例妊娠合并乙型肝炎孕妇作为观察组,选择同期无乙型肝炎的160例孕妇作为对照组,检测并比较两组的血脂水平及雌激素水平,分析影响妊娠合并乙型肝炎患者妊娠不良结局的危险因素。结果:血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)含量观察组均高于对照组,而高密度脂蛋白胆固醇(HDL-C)含量观察组明显低于对照组,差异均有统计学意义(P<0.05)。观察组与对照组的血清雌激素含量分别为(154.20±10.82)和(88.14±8.98)pmol·L~(-1),两组差异有统计学意义(t=8.109,P<0.05)。观察组剖宫产、产后出血、胎儿窘迫、新生儿窒息、妊娠期高血压疾病等发生情况均明显高于对照组(P<0.05)。Logistic多元回归分析显示,LDL-C≥3.0 mmol·L~(-1)、雌激素≥100 pmol·L~(-1)、年龄≥35岁、乙肝病程≥2年是妊娠合并乙型肝炎患者妊娠不良结局的危险因素(P<0.05)。结论:妊娠合并乙型肝炎的患者伴随有血脂异常与雌激素高表达,可导致妊娠不良结局发生率增加,两者都可作为妊娠合并乙型肝炎预后的预测指标。 Objective: To investigate the clinical significance of serum lipids and estrogen levels in pregnancy complicated with hepatitis B patients. Methods: A total of 160 pregnant women with pregnancy complicated with hepatitis B admitted to Shiyan Maternal and Child Health Care Hospital were selected as the observation group. 160 pregnant women without hepatitis B over the same period were selected as the control group. Blood lipid and estrogen levels were measured and compared between the two groups. Analysis of risk factors for adverse pregnancy outcome in patients with hepatitis B during pregnancy. Results: The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) in the observation group were higher than those in the control group, while the content of high density lipoprotein cholesterol (HDL-C) Lower than the control group, the difference was statistically significant (P <0.05). The levels of serum estrogen in the observation group and the control group were (154.20 ± 10.82) and (88.14 ± 8.98) pmol·L -1, respectively, with significant difference between the two groups (t = 8.109, P <0.05). The incidence of cesarean section, postpartum hemorrhage, fetal distress, neonatal asphyxia and gestational hypertension in the observation group were significantly higher than those in the control group (P <0.05). Logistic multiple regression analysis showed that LDL-C≥3.0 mmol·L -1, estrogen≥100 pmol·L -1, age≥35 years, duration of hepatitis B≥2 years was a risk factor for pregnancy complicated with hepatitis B Risk factors for poor outcome in pregnancy (P <0.05). Conclusion: Patients with pregnancy complicated with hepatitis B accompanied by dyslipidemia and high expression of estrogen can lead to an increased incidence of adverse pregnancy outcomes, both of which can be used as predictors of prognosis in pregnancy complicated with hepatitis B