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目的探讨妊娠糖尿病患者血小板和凝血功能参数变化,了解妊娠糖尿病患者凝血功能状态。方法选取2011年1月至2012年12月于广州市妇女儿童医疗中心产检的妊娠糖尿病患者150例(妊娠糖尿病组),同期门诊200例正常孕妇作为对照组,检测两组血小板计数(PLT)、血小板平均体积(MPV)、血小板体积分布宽度(PDW)参数以及凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)参数。结果与对照组比较,妊娠糖尿病组患者血小板计数偏低,PT、APTT明显缩短,MPV、PDW、FIB明显升高,差异均有统计学意义(P<0.05)。而TT变化不明显。结论妊娠糖尿病患者有明显的高凝状态,检测血小板和凝血功能指标对预防和治疗产科并发症有重要诊断价值。
Objective To investigate the changes of platelet and coagulation parameters in patients with gestational diabetes mellitus, and to understand the coagulation status of patients with gestational diabetes mellitus. Methods 150 cases (gestational diabetes mellitus) with gestational diabetes mellitus and 200 normal pregnant women in outpatient department during the same period were enrolled in this study from January 2011 to December 2012 in Guangzhou Women and Children Medical Center. The platelet count (PLT) (MPV), platelet volume distribution width (PDW) parameters and prothrombin time (PT), partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB) parameters. Results Compared with the control group, the platelet count of gestational diabetes mellitus group was lower, the PT, APTT, MPV, PDW and FIB were significantly higher (P <0.05). The TT change is not obvious. Conclusion The patients with gestational diabetes mellitus have obvious hypercoagulable state. The detection of platelet and coagulation indexes have important diagnostic value in the prevention and treatment of obstetric complications.