论文部分内容阅读
顺铂作为一种化疗药早在20世纪70年代便应用于肿瘤的临床治疗,它对许多部位的软组织肿瘤如睾丸癌、卵巢癌、肺癌和头颈部鳞癌都有较好的疗效,但它可引起耳毒性、肾毒性和神经毒性损伤。临床上耳毒性损伤主要包括耳鸣及高频听力损害。顺铂的致聋机理包括自由基机制、凋亡机制、?
As a chemotherapeutic drug, cisplatin has been used in the clinical treatment of tumors as early as the 1970s. It has good efficacy on many parts of soft tissue tumors such as testicular cancer, ovarian cancer, lung cancer and head and neck squamous cell carcinoma It can cause ototoxic, nephrotoxic and neurotoxic damage. Clinically, ototoxic lesions mainly include tinnitus and high frequency hearing loss. The mechanisms of desensitization of cisplatin include free radical mechanism, apoptosis mechanism,