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目的探讨玻璃体腔注射曲安奈德(intravitrealtriamcinoloneacetonide,IVTA)治疗糖尿病性黄斑水肿(diabeticmacularedema,DME)的疗效。方法回顾性分析25例(28只[)糖尿病性黄斑水肿患者,采用IVTA治疗,剂量为4mg/0.1ml。对比分析治疗前后视力,[压及黄斑区视网膜厚度变化。平均随访6个月。统计学方法采用SPSS13.0软件对各组数据进行处理(秩和检验、配对t检验)。结果治疗后1个月、3个月、6个月,平均视力由术前0.08±0.04分别提高到0.15±0.12、0.16±0.13、0.14±0.12,与治疗前比较差异有统计学意义(P<0.001)。OCT检查黄斑视网膜厚度术前平均为(599.89±135.65)μm,治疗后各时点分别为(249.70±74.69)μm、(243.18±73.19)μm和(245.54±69.33)μm。与治疗前比较有显著性差异(P<0.001)。5只[(17.9%)接受2次IVTA,第一、二次注药时间平均间隔为3个月。9只[(32.1%)[压升高(>21mmHg),局部或全身应用降[压药,[压均能控制正常。结论IVTA是治疗DME的有效方法,能有效改善黄斑水肿和提高视力,降低黄斑区视网膜厚度,但部分黄斑水肿复发,出现一过性[压升高,需进一步观察其长期疗效和安全性。
Objective To investigate the efficacy of intravitreal injection of triamcinolone acetonide (IVTA) in the treatment of diabetic macular edema (DME). Methods A retrospective analysis of 25 patients (28 diabetic patients with diabetic macular edema, using IVTA treatment, a dose of 4mg / 0.1ml. Contrast analysis of visual acuity before and after treatment, [pressure and macular retinal thickness changes. The average follow-up of 6 months. Statistical methods SPSS13.0 software for each group of data processing (rank sum test, paired t test). Results The average visual acuity increased from 0.08 ± 0.04 to 0.15 ± 0.12,0.16 ± 0.13 and 0.14 ± 0.12 at 1 month, 3 months and 6 months after treatment, respectively, with statistical significance (P < 0.001). The preoperative average thickness of macular retinal thickness was (599.89 ± 135.65) μm after OCT, and (249.70 ± 74.69) μm, (243.18 ± 73.19) μm and (245.54 ± 69.33) μm, respectively. Compared with before treatment, there was a significant difference (P <0.001). 5 [(17.9%) received 2 IVTA, the first and second injection time interval was 3 months. Nine [(32.1%) [elevated pressure (> 21mmHg), local or systemic application of pressure [pressure medicine, [pressure can control the normal. Conclusion IVTA is an effective method for the treatment of DME. It can effectively improve macular edema and improve visual acuity and reduce retinal thickness in macular area. However, some macular edema recurred and appeared transient (pressure increase, and its long-term efficacy and safety should be further observed.