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目的评估低剂量米非司酮(米福50mg)配伍米索前列醇600μg终止早孕的疗效和安全性,以及终止妊娠后的阴道流血情况。方法米福[米非司酮胶囊(Ⅱ)]总剂量50mg。第1天晨服米福20mg,12h后服10mg;第2天晨服米福10mg,12h后服10mg;第3天清晨口服米索前列醇600μg。对79例终止早孕的77例的年龄、停经天数、孕产次、B超子宫内孕囊大小进行比较分析,找出与阴道出血时间和出血量有关的因素。结果米福50mg终止早孕的有效率97.47%,和150mg制剂相当,但出血量较大的比例仅5.19%,阴道出血时间显著缩短。孕期越长,孕囊越大,出血时间则越长,出血量越大。结论低剂量米非司酮(米福50mg)配伍米索前列醇是一种安全有效的终止早孕方法。
Objective To evaluate the efficacy and safety of low-dose mifepristone (mifepristone 50mg) combined with misoprostol 600μg in the termination of early pregnancy, and vaginal bleeding after termination of pregnancy. Method Mifu [mifepristone capsules (Ⅱ)] The total dose of 50mg. The first day of morning service mofete 20mg, 12h after serving 10mg; the second day morning service mifek 10mg, 12h after serving 10mg; the third day morning oral misoprostol 600μg. 79 cases of termination of early pregnancy in 77 cases of age, days of menopause, gestational age, B ultrasound intrauterine gestational sac size were compared to find out the vaginal bleeding time and bleeding related factors. Results Mifu 50mg effective early termination of pregnancy 97.47%, and 150mg formulations, but the proportion of large bleeding was only 5.19%, significantly shorter vaginal bleeding time. The longer the pregnancy, gestational sac, the longer the bleeding time, the greater the amount of bleeding. Conclusion Low dose of mifepristone (Mifu 50mg) combined with misoprostol is a safe and effective method of termination of early pregnancy.