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目的:考察氨茶碱注射液与甲泼尼龙琥珀酸钠注射液的配伍稳定性。方法:采用HPLC法测定氨茶碱与甲泼尼龙琥珀酸钠的含量,观察和检测配伍液的外观及pH的变化。结果:将氨茶碱与甲泼尼龙琥珀酸钠配伍于5%葡萄糖注射液中,与配伍即刻(Oh)比较,8h内,配伍液无混浊、沉淀、气体产生,外观色泽及含量无明显变化,pH略有变化。结论:配伍液于室温下8h内基本稳定。
Objective: To investigate the compatibility of aminophylline injection with methylprednisolone sodium succinate injection. Methods: The contents of aminophylline and methylprednisolone sodium succinate were determined by HPLC, and the appearance and pH of the compatibility liquid were observed and detected. Results: Aminophylline and methylprednisolone sodium succinate in 5% glucose injection, compared with the compatibility (Oh), within 8h, compatibility no turbidity, precipitation, gas production, the appearance of color and content did not change significantly pH slightly changed. Conclusion: The compatibility solution is basically stable within 8 hours at room temperature.