[~(14)C]乙双吗啉给动物iv后,血中放射性一时间曲线符合二房室开放模型,药代动力学参数T1/2α=0.16±0.03h,T1/2β=15.1±0.7h,生物利用度为87.3±7.7%。给动物ig后,胃肠道吸收较慢,分布广,以胃、肝脏及肺组织中放射性为最高,其次为肠道、食道、肿瘤、淋巴结及皮肤等组织。连续ig 3天后,放射性主要分布在胸腺。48h 内iv自尿排泄为41.7±4.6%,大便排泄为7.5±1.0%;ig后自尿排泄为52.5±3.1%,大便排泄为7.9±0.3%。 Pharmacokinetic parameters T1 / 2α = 0.16 ± 0.03h, T1 / 2β = 15.1 ± 0.7h after the [~ (14) C] , Bioavailability was 87.3 ± 7.7%. After the animals ig, gastrointestinal absorption slow, widely distributed to the radioactive stomach, liver and lung tissue is highest, followed by intestinal, esophageal, tumor, lymph nodes and skin and other tissues. Three days after continuous ig, the radioactivity is mainly distributed in the thymus. 48h iv urine excretion was 41.7 ± 4.6%, stool excretion of 7.5 ± 1.0%; ig urine excretion was 52.5 ± 3.1%, stool excretion of 7.9 ± 0.3%.