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甲磺酸左氧氟沙星(Levofloxacin Mesylate,MSALVFX)是本所研制的一种新的氟喹诺酮类抗菌药,是氧氟沙星左旋体的甲磺酸盐。我们测定了甲磺酸左氧氟沙星的体外抗菌活性,并与同类药比较。实验结果表明,MSALVFX是一种广谱、抗菌活性强的喹诺酮类抗菌药,对革兰阳性菌的MIC为0.12～1μg/ml,对革兰阴性菌的MIC为0.002～1μg/ml。对临床分离致病菌871株的活性均与左氧氟沙星相似,是氧氟沙星的2倍。接种量、马血清、培养基pH值等因素对MSALVFX的抗菌活性无明显影响。MSALVFX的杀菌作用与左氧氟沙星、环丙沙星相当,比氧氟沙星强2倍。
Levofloxacin mesylate (Levofloxacin Mesylate, MSALVFX) is a new fluoroquinolone antibacterial agent developed by our institute, which is mesylate of ofloxacin levofloxacin. We measured in vitro antibacterial activity of levofloxacin mesylate and compared with similar drugs. The experimental results show that MSALVFX is a broad-spectrum and antibacterial quinolone antibacterial agent with a MIC of 0.12 ~ 1μg / ml against gram-positive bacteria and 0.002 ~ 1μg / ml against gram-negative bacteria. 871 strains of clinical isolates of pathogenic bacteria activity were similar to levofloxacin, ofloxacin 2 times. Inoculation amount, horse serum, medium pH and other factors had no significant effect on the antibacterial activity of MSALVFX. MSALVFX bactericidal effect and levofloxacin, ciprofloxacin quite, 2 times stronger than ofloxacin.