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目的分析替米沙坦对冠心病合并高血压患者的疗效及炎症因子的影响。方法选取2014年10月—2016年1月于栾川县人民医院接受诊治76例冠心病合并高血压患者,采用随机数字表法分为观察组(n=38)和对照组(n=38),两组均采用冠心病常规治疗,对照组加用硝苯地平缓释片治疗,观察组加用替米沙坦治疗,两组均治疗6个月。对比两组总有效率、治疗前和治疗6个月后SBP、DBP、IL-6、hs-CRP、TNF-α水平及安全性。结果观察组总有效率为94.74%(36/38),高于对照组总有效率78.95%(30/38),差异具有统计学意义(χ~2=4.145,P<0.05);与对照组相比,观察组治疗6个月后SBP和DBP水平较低,差异具有统计学意义(P<0.05);与对照组相比,观察组治疗6个月后IL-6、hs-CRP、TNF-α较低,差异具有统计学意义(P<0.05);不良反应发生率组间比较差异无统计学意义(χ~2=0.000,P>0.05)。结论冠心病合并高血压采用替米沙坦治疗,可显著改善患者临床症状和机体炎症状态,提高治疗效果,安全可靠,实用价值较高。
Objective To analyze the effect of telmisartan on the curative effect and inflammatory factors in patients with coronary heart disease complicated with hypertension. Methods From July 2014 to January 2016, 76 patients with coronary heart disease and hypertension were enrolled in Luanchuan People’s Hospital. Patients were randomly divided into observation group (n = 38) and control group (n = 38) , Both groups were treated with conventional coronary heart disease, the control group with nifedipine sustained-release tablets, the observation group plus telmisartan treatment, both groups were treated for 6 months. The total effective rate, SBP, DBP, IL-6, hs-CRP, TNF-α levels and safety before and 6 months after treatment were compared. Results The total effective rate in observation group was 94.74% (36/38), which was higher than that in control group (78.95%, 30/38), the difference was statistically significant (χ ~ 2 = 4.145, P <0.05) Compared with the control group, the levels of IL-6, hs-CRP, TNF in the observation group after 6 months of treatment were lower than those in the control group (P <0.05) -α was lower, the difference was statistically significant (P <0.05). The incidence of adverse reactions was no significant difference between the two groups (χ ~ 2 = 0.000, P> 0.05). Conclusion Treatment of telmisartan with coronary heart disease complicated with hypertension can significantly improve the clinical symptoms and the inflammatory state of the body and improve the therapeutic effect, which is safe and reliable, and has high practical value.