论文部分内容阅读
为确定胃肠道平滑肌肿瘤(GISMTs)较好的标志物。我们用α—平滑肌从动蛋白(ASMA)和结蛋白 (desmin)以ABC法对32列光镜下诊断的CISMTs进行了免疫化染色的对比研究。结果显示;27/32例是呈现ABMA阳性反应(84%),仅2/32例出现desmin阳性表达(6%)。良恶性 GISMTs 对 ASMA 染色反应无显著性差异(P<0.05)。ASMA较之desmin更为敏感、特异、尤其对不成熟的平滑肌细胞,ASMA又为一种增殖性肌标志。笔者认为,对平滑肌分化探测,ASMA明显优于desmin。因此, 作GISMTs鉴别,推荐常规使用ASMA。
To identify better markers of gastrointestinal smooth muscle tumors (GISMTs). We used ABC method to compare the immunostaining of CISMTs diagnosed by 32 light microscopes with α-smooth muscle actin (ASMA) and desmin (desmin). The results showed that 27/32 cases showed ABMA positive reaction (84%), and only 2/32 cases showed desmin positive expression (6%). There was no significant difference in the response of ASMA staining between benign and malignant GISMTs (P<0.05). ASMA is more sensitive, specific, especially immature smooth muscle cells than desmin, and ASMA is a proliferative muscle marker. The author believes that ASMA is superior to desmin in the detection of smooth muscle differentiation. Therefore, for the identification of GISMTs, ASMA is recommended for routine use.