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芳香醛化合物是重要的有机中间体,广泛应用于医药、农药等领域。研究介绍了一种合成苯环的邻、对位含有吸电子基团的芳香醛的改进工艺。分别以4-氯-2-硝基甲苯,4-硝基甲苯,4-氰基甲苯为原料,以N,N-二甲基甲酰胺(DMF)为溶剂,在140℃回流条件下与N,N-二甲基甲酰胺二甲缩醛(DMFDMA)合成相应的苯乙烯胺化合物,苯乙烯胺化合物再在过氧化氢的作用下氧化得到相应的芳香醛。论文主要是从溶剂、反应温度、H2O2的用量对产品收率的影响进行了研究,并确定了适宜的反应条件,在该反应条件下,不同醛的收率(4-氯-2-硝基苯甲醛,4-硝基苯甲醛,4-氰基苯甲醛)分别是:75.6%;58.3%;68.2%。该路线具有工艺简单,原料价廉且环境友好等优点。主要中间体和目标产物经高效液相色谱和1H-NMR核磁鉴定。
Aromatic aldehyde compounds are important organic intermediates, widely used in medicine, pesticides and other fields. In this paper, we introduce an improved process for synthesizing aromatic aldehydes with ortho and para positions of electron-withdrawing groups. Using 4-chloro-2-nitrotoluene, 4-nitrotoluene and 4-cyanotoluene as raw materials and N, N-dimethylformamide (DMF) , N-dimethylformamide dimethyl acetal (DMFDMA) Synthesis of the corresponding styrene amine compounds, styrene amine compounds and then under the action of hydrogen peroxide oxidation to give the corresponding aromatic aldehydes. The main contents of this thesis are the solvent, reaction temperature, the amount of H2O2 on the yield of the product were studied and the appropriate reaction conditions were determined. The yield of the aldehyde (4-chloro-2-nitro Benzaldehyde, 4-nitrobenzaldehyde, 4-cyanobenzaldehyde) were: 75.6%; 58.3%; 68.2%. The route has the advantages of simple process, cheap raw materials and environment-friendly. The main intermediates and target products were identified by high performance liquid chromatography and1H-NMR.