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对我院中毒职业病科及神经内科2014年10月—2016年10月收治的48例职业性慢性锰中毒及42例原发性帕金森病(IPD)患者的临床表现、头颅MRI检查及左旋多巴治疗效果进行比较。结果显示,两组患者锥体外系神经受损症状、肌张力增高、运动迟缓、静止性震颤等临床症状和体征相似;平均发病年龄、运动状态、肌张力增高状况、症状/体征对称性、MRI特征、左旋多巴胺类药物替代疗效等有明显不同。提示临床医师应对职业性锰中毒与IPD的临床特点进行比较,提高两种疾病诊断的正确率,早期治疗及干预,改善神经功能,延缓病情进展。
48 cases of occupational chronic manganese poisoning and 42 cases of idiopathic Parkinson’s disease (IPD) admitted to our hospital from October 2014 to October 2016 were analyzed retrospectively. The clinical manifestations, head MRI and L-plus Pakistan treatment effect comparison. The results showed that the clinical symptoms and signs of extrapyramidal nerve injury symptoms, increased muscle tone, bradykinesia, rest tremor were similar in both groups. The average age of onset, motor status, increased muscle tone, symmetry of symptoms / signs, Characteristics, alternative effects of L-dopamine drugs have obvious differences. It is suggested that clinicians should compare the clinical features of occupational manganese poisoning and IPD to improve the accuracy of diagnosis of both diseases, early treatment and intervention, improve neurological function and delay the progression of the disease.