论文部分内容阅读
多种动物脑室注射东莨菪碱均引起麻醉现象。由埋入颅顶蛛网膜下腔的套管注入东莨菪碱,阻断皮层胆碱能系统,脑电呈现高压慢波,动物保持清醒状态。东莨菪碱注入脑内不同部位,只有注入中脑、间脑交界处的近中线部位,尤其是中央灰质及其腹侧的脑区,出现翻正反射消失的浅麻醉状态。证实东莨菪碱麻醉作用主要是阻断了胆碱能受体,依色林拮抗这一作用。这一部位胆碱能受体的正常功能对意识、清醒及翻正反射极其重要。脑内注射东茛菪碱对大鼠回避性条件反射的抑制,以杏仁核抑制作用最强。这一部位可能是东茛菪碱麻醉后引起健忘的主要作用部位之一。
A variety of animal intraventricular injection of scopolamine are caused by anesthesia. Intramural subarachnoid embedded by the cannula into the scopolamine, blocking the cortical cholinergic system, EEG showed high pressure slow wave, the animals remain awake. Scopolamine injected into different parts of the brain, only injected into the midbrain and diencephalon at the junction of the midline, especially the central gray matter and ventral brain area, appear inverted reflex shallow anesthesia. Confirmed that the main role of scopolamine anesthesia is to block the cholinergic receptor, eczema antagonism of this effect. The normal function of the cholinergic receptors in this site is extremely important for awareness, awakeness and reflex. Intracerebral injection of scopolamine on rats avoidance reflex inhibition, the strongest inhibitory effect of the amygdala. This site may be one of the major sites of forgetfulness caused by scopolamine anesthesia.