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目的总结百草枯中毒急性肺损伤患者的临床特点,分析发病机制和诊断治疗体会。方法回顾性分析遵义医学院附属医院2007年4月至2010年6月7例口服百草枯中毒患者的临床资料。结果所有患者均为口服中毒,均合并多脏器功能不全,主要表现在肝、肾、肺三大器官,其中肝、肾最先受累,后期均并发急性肺损害,7例患者最终均因多脏器功能衰竭而死亡,死亡最主要原因为急性肺损伤、呼吸衰竭。结论百草枯中毒病死率极高,治疗效果差,发病凶险,死亡主要原因为多脏器功能不全,尤其是肺损伤致急性呼吸功能不全,且无特效治疗方法,预后极差。
Objective To summarize the clinical characteristics of patients with paraquat poisoning acute lung injury, analyze the pathogenesis and diagnosis and treatment experience. Methods The clinical data of 7 paraquat poisoning patients from April 2007 to June 2010 in Zunyi Medical College Affiliated Hospital were retrospectively analyzed. Results All patients were orally poisoned. All of them were complicated with multiple organ dysfunction. The main manifestations were liver, kidney and lung. The first liver and kidney involved, and the latter acute lung injury. The final result of 7 patients Organ failure and death, the leading cause of death was acute lung injury, respiratory failure. Conclusion Paraquat poisoning has a very high mortality rate, poor curative effect and dangerous morbidity. The main cause of death is multiple organ dysfunction, especially acute respiratory insufficiency caused by lung injury. There is no specific treatment and the prognosis is very poor.