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目的研究肺结核患者血小板参数、D-二聚体及纤维蛋白原(Fg)水平的变化及其临床意义。方法测定100例肺结核患者(其中活动性肺结核、非活动性肺结核患者各50例)及50例健康体检者(对照组)的血小板参数、D-二聚体及纤维蛋白原水平,并进行比较。结果活动性肺结核组、非活动组与对照组比较,D-二聚体及纤维蛋白原(Fg)、血小板计数(PLT)、平均血小板容积(MPV)水平显著增加,差异有统计学意义(P<0.05),且活动性肺结核组较非活动组升高更为明显,差异有统计学意义(P<0.05);而血小板分布宽度(PDW)及大血小板比率(P-LCR)3组间无明显变化。D-二聚体及Fg、PLT、MPV水平在抗结核治疗后呈显著下降,差异有统计学意义(P<0.05)。结论肺结核患者体内存在高凝状态,监测上述指标,对预防血栓性并发症有重要临床意义。
Objective To study the changes of platelet parameters, D-dimer and fibrinogen (Fg) in patients with pulmonary tuberculosis and their clinical significance. Methods Platelet parameters, D-dimer and fibrinogen levels in 100 patients with tuberculosis (50 active tuberculosis, 50 inactive tuberculosis patients) and 50 healthy controls (control group) were measured and compared. Results Compared with the control group, the levels of D-dimer, fibrinogen (Fg), platelet count (PLT) and mean platelet volume (MPV) in active pulmonary tuberculosis group and inactive group were significantly increased (P <0.05), and the active tuberculosis group was more significant than the inactive group, the difference was statistically significant (P <0.05); while the platelet distribution width (PDW) and large platelet ratio (P-LCR) obvious change. D-dimer and Fg, PLT, MPV levels after anti-TB treatment was significantly decreased, the difference was statistically significant (P <0.05). Conclusions There is hypercoagulable state in patients with pulmonary tuberculosis. Monitoring the above indexes has important clinical significance in preventing thrombotic complications.