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6名健康年轻受试者(HY)、6名健康老年受试者(HE)和6例慢性心衰老年病人(CF),每天接受赖诺普利(lisinopril)5mg,共7天。定期收集血样和尿样,测定有关参数。结果表明,HE和CF使用本品24小时后和7天的血清药浓度明显高于HY(p<0.05)。HY和HE之间药物血浆浓度的AUC无显著差异。HY7天AUC值比CF低(p<0.01)。
Six healthy young subjects (HY), six healthy elderly subjects (HE) and six chronic heart failure elderly patients (CF) received lisinopril 5 mg daily for 7 days. Blood samples and urine samples were collected periodically to determine the relevant parameters. The results showed that serum concentrations of HE and CF after 24 hours and 7 days were significantly higher than HY (p <0.05). There was no significant difference in AUC of drug plasma concentration between HY and HE. HY7 day AUC values were lower than CF (p <0.01).