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目的:探讨不同剂量乌司他丁对急性胰腺炎患者血清TNF-α、IL-1、IL-6、IL-8含量影响。方法:收集我院消化内科收治的急性胰腺炎患者72例,随机分为试验组和对照组,各36例。对照组予以10万IU静点,每8 h 1次;试验组患者予以乌司他丁30万IU静点,每8 h 1次。治疗后比较患者临床症状、血清TNF-α、IL-1、IL-6、IL-8含量、血淀粉酶、肝脏功能以及不良反应发生情况。结果:治疗后,与治疗前相比两组AMY、ALT以及Cr水平均降低(P<0.05),血清TNF-α、IL-1、IL-6、IL-8水平均降低(P<0.05)。与对照组相比,试验组治疗有效率较高(P<0.05);试验组临床症状消失时间、实验室指标恢复时间以及住院天数缩短(P<0.05);试验组TNF-α、IL-1、IL-6、IL-8水平较低(P<0.05);试验组AMY、ALT以及Cr水平较低(P<0.05)。结论:大剂量乌司他丁应用于急性胰腺炎的治疗安全有效,较正常剂量相比,能够缩短治疗时间,降低TNF-α、IL-1、IL-6、IL-8等炎症因子水平。
Objective: To investigate the effects of different doses of ulinastatin on serum TNF-α, IL-1, IL-6 and IL-8 levels in patients with acute pancreatitis. Methods: Seventy-two patients with acute pancreatitis admitted to our hospital for digestive medicine were randomly divided into experimental group and control group with 36 cases each. The control group was given 100,000 IU static points, once every 8 hours. Patients in the test group were given ulinastatin 300,000 IU intravenous injection once every 8 hours. After treatment, clinical symptoms, serum TNF-α, IL-1, IL-6 and IL-8 levels, serum amylase, liver function and adverse reactions were compared. Results: After treatment, the levels of AMY, ALT and Cr in both groups decreased (P <0.05) and the levels of TNF-α, IL-1, IL-6 and IL- . Compared with the control group, the experimental group had a higher effective rate of treatment (P <0.05); the disappearance time of clinical symptoms, the recovery time of laboratory indexes and the days of hospitalization were shorter in the experimental group (P <0.05); The levels of TNF-α and IL- , IL-6 and IL-8 levels were lower (P <0.05). The levels of AMY, ALT and Cr in the experimental group were lower (P <0.05). Conclusion: The high dose of ulinastatin is safe and effective in the treatment of acute pancreatitis. Compared with the normal dose, ulinastatin can shorten the treatment time and decrease the levels of inflammatory factors such as TNF-α, IL-1, IL-6 and IL-8.