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用免疫印迹术 ( IBT)对 70例系统性红斑狼疮 ( SLE)患者进行了 7种可提取性核抗原 ( ENA)的自身抗体检测。 70例SL E患者中有 5 5例 ( 78.6% )患者检出至少一种自身抗体。 SLE的特异性抗体抗 Sm抗体阳性率达 47.1%。抗 r RNP抗体阳性率达15 .7%。抗 u1 RNP抗体、抗 SSA抗体和抗 SSB抗体阳性率分别为 5 5 .7%、42 .9%和 2 4.3 %。 70例 SLE的 7种自身抗体与抗 ds-DNA抗体总的阳性符合率为 75 .6%。两种方法同时测定有助于提高 SL E的诊断阳性率
Seventy patients with systemic lupus erythematosus (SLE) were tested for autoantibodies against seven extractable nuclear antigens (ENAs) using Western blotting (IBT). Fifty-five (78.6%) of the 70 SL E patients had at least one autoantibody detected. The positive rate of SLE-specific anti-Sm antibody was 47.1%. Anti-r RNP antibody positive rate of 15.7%. The positive rates of anti-u1 RNP antibody, anti-SSA antibody and anti-SSB antibody were 55.7%, 42.9% and 22.3% respectively. The overall positive coincidence rate of the seven autoantibodies of 70 SLE patients with anti-dsDNA antibody was 75.6%. Simultaneous determination of the two methods can help increase the diagnostic positive rate of SLE