大量研究发现绝经较早的女性发生心血管疾病的危险性增加。过去一致认为心血管疾病危险性增加是绝经的结果,而相反的假设却一直没有人去研究,即绝经前心血管疾病危险因素的增加使绝经期提前到来。为研究心血管疾病危险因素是否加速绝经,该研究从1948年起,在Fram ingham心脏中心 Numerous studies have found that women with early menopause have an increased risk of cardiovascular disease. In the past it was unanimously agreed that the increased risk of cardiovascular disease is the result of menopause, and the opposite assumption has not been studied, that is, menopausal advance comes earlier due to increased risk of pre-menopausal cardiovascular disease. To investigate whether cardiovascular disease risk factors accelerate menopause, this study began in 1948 in the heart of Fram ingham