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目的:观察小儿防哮敷贴粉对小儿支气管哮喘的治疗效果及对血清25-(OH)D3、Ig E的影响。方法:100例哮喘患儿随机分为4组,哮喘对照组采用普米克令舒(20min/次、2次/d)治疗3个月,小儿防哮敷贴粉各剂量(30min/次,1次/d,早上用一贴)、(30min/次,2次/d,早晚各用一贴)、(30min/次,3次/d,早中晚各用一贴)治疗3个月。选取26例健康儿童作为正常对照组。观察治疗效果、临床症状体征持续时间、肺功能,放射免疫法测血清25-(OH)D3、Ig E的变化。结果:小儿防哮敷贴粉(30min/次,2次/d,早晚各用一贴)、(30min/次,3次/d,早中晚各用一贴)剂量症状体征持续时间均明显降低,4组治疗后FEV1、PEF均较治疗前明显增高,小儿防哮敷贴粉(30min/次,3次/d,早中晚各用一贴)治疗后FEV1、PEF较哮喘对照组明显升高,哮喘对照25-(OH)D3明显降低,Ig E明显升高;小儿防哮敷贴粉(30min/次,2次/d,早晚各用一贴)、(30min/次,3次/d,早中晚各用一贴)25-(OH)D3明显增高,Ig E明显降低。结论:小儿防哮敷贴粉(30min/次,2次/d,早晚各用一贴)、(30min/次,3次/d,早中晚各用一贴)治疗小儿哮喘的临床疗效显著,其机制可能与影响血清25-(OH)D3、Ig E含量有关。
Objective: To observe the therapeutic effect of pediatric anti-asthma powder on children with bronchial asthma and its effect on serum 25- (OH) D3 and IgE. Methods: One hundred children with asthma were randomly divided into 4 groups. The asthma control group was treated with Pulmicort respules (20 min / time, twice daily) for 3 months. Pediatric anti-asthma powder application (30 min / (30min / time, 2 times / d, morning and evening each with a paste), (30min / times, 3 times / d, early in the evening with a paste) for 3 months. Twenty-six healthy children were selected as normal control group. The therapeutic effect, duration of clinical signs and symptoms, lung function and radioimmunoassay were used to measure the changes of serum 25- (OH) D3 and IgE. Results: Pediatric anti-asthma powder (30min / time, 2 times / d, morning and evening with a paste), (30min / times, 3 times / d, early in the evening with a paste) dose symptoms were significantly longer duration The FEV1 and PEF in the four groups were significantly higher than those before treatment, and the FEV1 and PEF in pediatric anti-asthma powder (30min / time, 3 times / d, (OH) D3 was significantly decreased and IgE was significantly increased in children with asthma. Anti-asthma powder in children (30min / time, 2 times / d, morning and evening each with a paste), 30min / / d, early in the evening with a paste) 25- (OH) D3 was significantly higher, Ig E significantly lower. Conclusion: Pediatric anti-asthma powder (30min / time, 2 times / d, morning and evening with a paste), (30min / times, 3 times / d, , The mechanism may be related to the impact of serum 25- (OH) D3, Ig E levels.