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目的:观察半夏泻心汤对合并幽门螺杆菌感染大鼠慢性胃炎模型胃粘液层磷脂和氨基己糖的影响,进一步探讨其作用机理。方法:采用脱氧胆酸钠自由饮用、灌服乙醇溶液、饥饱失常、HP感染等综合法制成大鼠慢性胃炎合并HP感染模型,观察半夏泻心汤对大鼠胃粘液层磷脂和氨基己糖含量的变化。结果:半夏泻心汤大剂量组显著增加大鼠胃粘液层磷脂和氨基己糖含量,与阴性对照组比较有非常显著性差异(P<0.01),小剂量组能增加大鼠胃粘液层磷脂含量,与阴性对照组比较有显著性差异(P<0.05)。结论:半夏泻心汤有增加胃粘液层磷脂和氨基已糖含量的作用,对胃粘膜屏障有一定的保护作用。
OBJECTIVE: To observe the effect of Banxia Xiexin Decoction on the phospholipid and hexosamine in gastric mucosa of chronic gastritis model rats infected with Helicobacter pylori, and further explore its mechanism. METHODS: A rat model of chronic gastritis combined with HP infection was made by using a combination of sodium deoxycholate free drinking, oral ethanol solution, hunger-saturation, and HP infection. Observed the effect of Banxia Xiexin Decoction on rat stomach mucin layer of phospholipid and aminohexamine. Changes in sugar content. Results: The high-dose Banxia Xiexin Decoction group significantly increased the content of phospholipids and hexosamines in the gastric mucus layer of rats, and there was a significant difference compared with the negative control group (P<0.01). The low-dose group could increase the gastric mucus layer in rats. Phospholipid content was significantly different from the negative control group (P<0.05). Conclusion: Banxia Xiexin Decoction can increase the content of phospholipids and aminohexoses in gastric mucus layer, and it has a protective effect on gastric mucosal barrier.