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目的分析卡前列素氨丁三醇与缩宫素联合用药方案在高危产妇剖宫产产后出血中的预防效果,且观察产妇用药后的不良反应发生情况。方法收集东莞市寮步医院产科接诊的拟行剖宫产分娩的高危妊娠产妇120例,将所有产妇随机分成3组:甲组40例,单纯给予缩宫素治疗;乙组40例,给予缩宫素与卡前列甲酯栓联合方案治疗;丙组40例,给予缩宫素与卡前列素氨丁三醇联合方案治疗。比较3组患者的术中、术后出血量,产后出血情况、治疗情况与不良反应发生情况。结果乙组与丙组的术中和术后2 h出血量均显著低于甲组(P<0.05),其中又以丙组的差异更为显著。丙组的术后2~24 h出血量显著低于甲组和乙组(P<0.05)。乙组与丙组患者的产后出血发生率、输血率、行其他止血措施治疗率均显著低于甲组(P<0.05)。结论卡前列素氨丁三醇与缩宫素联合用药方案能够有效降低高危产妇的剖宫产产后出血量和产后出血发生率,安全性较高,值得进一步推广。
Objective To analyze the prophylactic effects of combination therapy with carboprost and oxytocin on bleeding after cesarean section in high-risk maternal women and to observe the adverse reactions after maternal medication. Methods A total of 120 pregnant women with high-risk pregnancies undergoing cesarean delivery were collected from obstetric department of Liaobu Hospital of Dongguan City. All pregnant women were randomly divided into 3 groups: 40 cases in group A, treated with oxytocin alone; 40 cases in group B, Oxytocin and card forefront of methyl ester suppository program; Group C 40 cases, given oxytocin and carboplatin combination of trometamol regimen. Three groups of patients were compared intraoperative and postoperative bleeding, postpartum hemorrhage, treatment and adverse reactions. Results The intraoperative and postoperative 2 h hemorrhages in group B and group C were significantly lower than those in group A (P <0.05), and the difference between group C and group C was more significant. The bleeding volume in group C was significantly lower than that in group A and group B after 2 ~ 24 h (P <0.05). The incidence of postpartum hemorrhage, transfusion rate and other hemostatic measures in group B and group C were significantly lower than that in group A (P <0.05). Conclusion The combination of carboprost trometamol and oxytocin can effectively reduce the postpartum hemorrhage rate and the postpartum hemorrhage rate of cesarean section in high-risk women, which is safe and worthy of further promotion.