膜性肾病以蛋白尿为主要表现,缓慢发病,70%～80%呈肾病综合征。膜性肾病分为原发性和继发性二大类,前者原因不明,约占80%,后者伴发于恶性肿瘤、自身免疫性疾病、病毒性肝炎及药物。本文主要概述原发性膜性肾病肾功能预后不良组的治疗现状。一、组织学分类组织学上分为4期,主要 Membranous nephropathy to proteinuria as the main performance, slow onset, 70% to 80% were nephrotic syndrome. Membranous nephropathy is divided into two major categories of primary and secondary, the former unexplained, about 80%, the latter associated with malignant tumors, autoimmune diseases, viral hepatitis and drugs. This article summarizes the treatment of primary membranous nephropathy poor prognosis of renal function group. First, the histological classification Histologically divided into four, mainly