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微胶囊在药物递送系统中具有重要的应用价值.目前关于该领域的研究主要集中于开发新型微胶囊来提高药物递送系统的效率.本文提出了一种可协同运输和缓慢释放药物的微胶囊,其由明胶甲基丙烯酸接枝共聚物(GelMa)内核和聚乳酸羟基乙酸共聚物(PLGA)外壳组成.在微胶囊的制备过程中,使用液滴微流控技术,将溶有盐酸阿霉素(DOX)的GelMa水溶液和溶有喜树碱(CPT)的PLGA油溶液乳化成均匀的双乳液模板,通过紫外固化模板内核,通过溶剂挥发固化模板壳层.该过程避免了乳液的破损及包裹液的流出,因此可显著提高药物的包裹效率.通过调节微流控的流速,还可精确地调节微粒的尺寸和结构.由于所制备的微胶囊内核和外壳都为固化状态,其包裹的活性药物只能随着载体材料的降解而缓慢释放出来,这就避免了其他种类药物载体所面临的药物突释现象.本研究所开发的微胶囊的这些优良特性使其成为药物递送系统中的理想选择.
Microcapsules have important application value in drug delivery system.At present, the research in this field mainly focuses on the development of new microcapsules to improve the efficiency of drug delivery system.In this paper, we propose a microcapsule that can co-transport and slowly release drugs, Which consists of a gelatin methacrylate graft copolymer (GelMa) core and a polylactic acid glycolic acid copolymer (PLGA) shell composition in the preparation of microcapsules, the use of droplet microfluidic technology will be dissolved doxorubicin hydrochloride (DOX) GelMa aqueous solution and camptothecin (CPT) -containing PLGA oil solution were emulsified into a uniform double emulsion template, and the template shell was cured by solvent evaporation by UV curing of the template core. This process avoids emulsion breakage and entrapment Can significantly improve the efficiency of the drug package by adjusting the flow rate of microfluidic, but also can accurately adjust the size and structure of the particles due to the prepared microcapsule core and the shell are in a cured state, the active drug wrapped Can only slowly release with the degradation of the carrier material, which avoids the drug burst phenomenon that other kinds of drug carriers are faced with. The micro-glue These excellent properties make it ideal for drug delivery systems.