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本文报道62例多原发恶性肿瘤(MPMN)的免疫组织化学在病理诊断中的意义,尤其是51例发生在同一系统、同一器官或对称性器官,且组织结构相似的MPMN,颇难定原发或继发。通过免疫组织化学(CEA、HCG和K_(12))研究发现:MPMN的不同癌灶中,3种免疫组化染色常不相同。而对照组中,原发灶和继发灶两者反应基本一致。研究结果提示,MPMN灶可能具有各自的代谢和功能特性。应用免疫组化方法可能有助于与继发性癌瘤相鉴别。
This article reports the significance of immunohistochemistry in 62 cases of multiple primary malignant tumors (MPMN) in the pathological diagnosis, especially in 51 cases of the same system, the same organ or symmetrical organs, and similar organizational structure of MPMN, quite difficult to set the primary Or secondary. Immunohistochemistry (CEA, HCG and K_ (12)) study found that: MPMN different foci, the three immunohistochemical staining often different. The control group, the primary tumor and secondary reaction was basically the same. The results suggest that MPMN foci may have their own metabolic and functional properties. Application of immunohistochemical methods may help differentiate from secondary cancers.