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目的探讨在大肠腺瘤以及大肠癌组织中环氧化酶-2(COX-2)的表达及其临床病理意义。方法应用免疫组织化学的方法,检测COX-2在10例正常大肠黏膜组织、23例大肠腺瘤组织以及31例大肠癌组织中的表达情况。结果COX-2在正常大肠黏膜组织中无表达,COX-2在大肠腺瘤组织中的表达率为26.1%(6/23);COX-2在大肠癌组织中的表达率为71.0%(22/31),与正常大肠黏膜组织比较差异有统计学意义(P<0.05)。在大肠癌中COX-2的表达与是否有淋巴结转移有关,差异有统计学意义(P<0.05),与其他临床病理因素无关,差异无统计学意义(P>0.05)。结论 COX-2可能在大肠癌发生、发展中发挥了作用。
Objective To investigate the expression of cyclooxygenase-2 (COX-2) in colorectal adenoma and colorectal carcinoma and its clinicopathological significance. Methods Immunohistochemical method was used to detect the expression of COX-2 in 10 cases of normal colorectal mucosa, 23 cases of colorectal adenoma and 31 cases of colorectal cancer. Results COX-2 was not expressed in normal colorectal mucosa, the expression of COX-2 in colorectal adenoma was 26.1% (6/23), and the expression of COX-2 in colorectal carcinoma was 71.0% (22 / 31), compared with normal colorectal mucosa, the difference was statistically significant (P <0.05). The expression of COX-2 in colorectal cancer was correlated with lymph node metastasis (P <0.05), but not with other clinicopathological factors. There was no significant difference (P> 0.05). Conclusion COX-2 may play a role in the occurrence and development of colorectal cancer.