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目的 :观察 1,6-二磷酸果糖 (FDP)治疗新生儿缺氧缺血性脑病 (HIE)合并心肌损害的疗效。方法 :将 5 9例患儿随机分成两组 ,对照组 3 2例 ,治疗组 2 7例。两组均采用多巴酚丁胺等常规治疗 ,治疗组加用FDP 2 0 0～ 2 5 0mg/(kg·次 ) ,静脉注射。结果 :治疗组心率恢复至 12 0次 /min时间明显短于对照组 ,多巴酚丁胺用量明显低于对照组 ,差异均有显著意义 (P <0 0 1) ,未发现不良反应。结论 :FDP治疗HIE合并心肌损害疗效显著。
Objective: To observe the effect of fructose-1,6-diphosphate (FDP) on neonatal hypoxic-ischemic encephalopathy (HIE) complicated with myocardial damage. Methods: Fifty-nine children were randomly divided into two groups: control group (n = 32) and treatment group (n = 27). Both groups were treated with dobutamine and other conventional therapy, the treatment group plus FDP 200 ~ 250mg / (kg · times), intravenous injection. Results: The heart rate of the treatment group recovered to 120 times / min significantly shorter than that of the control group, and the dosage of dobutamine was significantly lower than that of the control group (P <0.01). No adverse reactions were found. Conclusion: FDP treatment of HIE complicated with myocardial injury significant effect.