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目的研究室性早搏(Ventricular premature beats,VPBs)及其心外膜脂肪组织(Epicardial fat tissue,EFT)厚度的关系。方法收集经24小时动态电心图检查诊断为室早搏患者共48例,疑似室性早搏患者共30例作为对照组。经超声测量心外膜脂肪组织厚度,对各组之间的心外膜脂肪厚度进行比较。结果室性早搏患者心外膜脂肪组织厚度(3.3±1.3)mm显著高于对照组(2.2±0.8)mm,差异有统计学意义(t=6.471,P<0.01)。心外膜脂肪厚度与年龄、体重指数(BMI)、低密度脂蛋白胆固醇(LDL-C)呈正相关(r=0.284、0.253、0.132,P<0.05),与高密度脂蛋白胆固醇(HDL-C)呈负相关。ROC曲线示心外膜脂肪厚度为7.0mm时,敏感度为80.6%,特异度为65.7%,ROC曲线下面积为0.839,95%CI:0.76~0.93(P<0.01)。结论室性早搏患者心外膜脂肪厚度明显高于对照组,心外膜脂肪显著增厚可能是室性早搏发生的一个危险因素。
Objective To study the relationship between the thickness of ventricular premature beats (VPBs) and epicardial fat tissue (EFT). Methods A total of 48 cases of premature ventricular contractions were diagnosed by dynamic electrocardiogram examination in 24 hours. Thirty patients with suspected premature ventricular contractions were selected as control group. The thickness of epicardial adipose tissue was measured by ultrasound and the thickness of epicardial fat between the groups was compared. Results The thickness of epicardial adipose tissue in patients with premature beats (3.3 ± 1.3) mm was significantly higher than that in controls (2.2 ± 0.8) mm, the difference was statistically significant (t = 6.471, P <0.01). Epicardial fat thickness was positively correlated with age, body mass index (BMI) and low density lipoprotein cholesterol (LDL-C) (r = 0.284,0.253,0.132, P < ) Was negatively correlated. The ROC curve showed a sensitivity of 80.6% and a specificity of 65.7% with an epicardial fat thickness of 7.0 mm. The area under the ROC curve was 0.839 and 95% CI: 0.76 to 0.93 (P <0.01). Conclusion The epicardial fat thickness in patients with premature ventricular contractions is significantly higher than that in the control group. Significant epicardial fat thickening may be a risk factor for premature ventricular contractions.