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目的探讨体质指数(BMI)、腰臀比(WHR)、体脂肪率(FAT%)与动脉硬化的相关性。方法 2005年1月—2010年5月,以在某医院健康体检中心进行体检并接受人体成分检测及动脉硬化评价的成人26 599人为研究对象,其中男性13 663例(51.37%),女性12 936例(48.63%),平均年龄(45.91±8.07)岁,同时进行血脂、血糖、尿酸等指标的检测,用BMI、WHR、FAT%描述性分析人群肥胖的情况,用颈股脉搏波传导速度(cfPWV)、颈桡脉搏波传导速度(crPWV)来评价动脉硬化,用简单相关及多元逐步回归分析各种肥胖指标与动脉硬化的相关性。结果青年男性和女性WHR与cfPWV均相关(r=0.191,P=0.005;r=0.306,P<0.001),女性BMI也与cfPWV相关(r=0.175,P=0.006);中年男性和女性WHR与cfPWV均相关(r=0.239,P<0.001;r=0.189,P<0.001),男性FAT%与crPWV相关(r=0.186,P=0.001),女性FAT%与cfPWV及crPWV相关(r=0.050,P=0.032;r=0.174,P=0.001);老年男性WHR与cfPWV及crPWV相关(r=0.134,P=0.011;r=0.145,P=0.001),FAT%与cfPWV相关(r=0.168,P=0.003),老年女性WHR与cfPWV相关(r=0.093,P=0.017),FAT%与cfPWV及crPWV相关(r=0.111,P=0.009;r=0.116,P=0.015)。在调整血压、血脂、血糖、尿酸等因素后,多元逐步回归的结果表明,中年男性WHR与cfPWV独立相关(P<0.05),老年男性WHR与cfPWV、crPWV独立相关(P<0.05)。青年、中年、老年女性的WHR均与cfPWV独立相关(P<0.05),老年女性FAT%与crPWV独立相关(P<0.05)。结论 WHR是PWV的独立相关因素,而BMI与PWV无独立相关关系,老年女性的FAT%是crPWV的独立相关因素。
Objective To investigate the relationship between body mass index (BMI), waist-hip ratio (WHR), body fat percentage (FAT%) and atherosclerosis. Methods From January 2005 to May 2010, 26 599 adults, who underwent physical examination in a health examination center of a hospital and were evaluated for body composition and atherosclerosis, were enrolled in this study. Among them, 13,663 (51.37%) were male and 12,936 (48.63%), average age (45.91 ± 8.07) years old, at the same time, blood lipid, blood glucose, uric acid and other indicators of detection, with BMI, WHR, FAT% descriptive analysis of population obesity, with neck palsy pulse wave velocity cfPWV) and carotid radial pulse wave velocity (crPWV) were used to evaluate arteriosclerosis. The correlation between various obesity indices and atherosclerosis was analyzed by simple correlation and multiple stepwise regression. Results Both WHR and CFPWV were found in young males and females (r = 0.191, P = 0.005; r = 0.306, P <0.001). BMI was also associated with cfPWV (r = 0.175, P = 0.006) (R = 0.186, P = 0.001). There was a significant association between cfPWV and crPWV (r = 0.050, r = 0.189, P <0.001) (R = 0.134, P = 0.011; r = 0.145, P = 0.001). There was a significant correlation between FAT% and cfPWV (r = 0.168, (R = 0.111, P = 0.009; r = 0.116, P = 0.015). In the elderly women, WHR was associated with cfPWV (r = 0.093, P = 0.017). Fat% was associated with cfPWV and crPWV. The results of multivariate stepwise regression showed that WHR was independently associated with cfPWV in middle-aged men (P <0.05), and WHR in elderly men was independently associated with cfPWV and crPWV (P <0.05) after adjustment for blood pressure, blood lipid, blood glucose and uric acid. The WHR of young, middle-aged and elderly women were independently associated with cfPWV (P <0.05), and the percentage of fat% of elderly women was independently associated with crPWV (P <0.05). Conclusions WHR is an independent factor related to PWV, while BMI has no independent relationship with PWV. Fat% of elderly women is independent factor of crPWV.