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目的 对 6例系统性红斑狼疮 (SLE)终末期肾病患者的肾移植情况进行总结。方法 对 6例终末期狼疮肾病肾移植患者的临床、实验室资料和手术后随访情况进行分析。结果 6例患者均为女性 ,平均病程 4 4年 ,进行移植手术时全身病情稳定 ;术前均使用激素和 /或免疫抑制剂控制SLE病情 ,手术后免疫抑制剂使用情况差异无显著性 ,术后平均随诊时间为 2 4 2个月 ,无 1例发生急、慢性排异反应及狼疮肾病复发 ,移植肾功能良好。结论 终末期狼疮肾病患者的移植肾存活及功能状况良好 ,无狼疮肾病复发 ,肾移植是治疗终末期狼疮肾病的有效方法之一
Objective To summarize the renal transplantation in 6 patients with systemic lupus erythematosus (SLE) with end-stage renal disease. Methods Clinical, laboratory data and postoperative follow-up of 6 patients with end stage lupus nephropathy were analyzed. Results All the 6 patients were female, with an average duration of 44 years. The systemic condition was stable during the transplantation. The hormones and / or immunosuppressive agents were used to control the SLE before operation. There was no significant difference in the use of immunosuppressive agents after operation After an average follow-up time of 224 months, none of acute and chronic rejection and lupus nephropathy relapse, renal transplant function. Conclusions The survival and functional status of graft in patients with end stage lupus nephropathy are good, with no recurrence of lupus nephropathy. Renal transplantation is one of the effective methods for the treatment of lupus nephropathy